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Penicillin-binding protein 1C

Molecular classification: Enzyme, Penicillin-binding protein, Transglycosylase, Transpeptidase

Overview

Penicillin-binding protein 1C (PBP1C) is a bacterial enzyme involved in the synthesis of peptidoglycan, an essential component of the bacterial cell wall in Gram-negative bacteria such as Escherichia coli. It belongs to the family of penicillin-binding proteins (PBPs) and possesses both transglycosylase and transpeptidase activity, catalyzing peptidoglycan polymerization and cross-linking, respectively. It is a target for β-lactam antibiotics.

Mechanism of action

Inhibition of transpeptidase activity via acylation of active site serine residue (β-lactams); Inhibition of transglycosylase activity (Moenomycin).

Biological functions

Peptidoglycan biosynthesisCell wall synthesisMurein polymerizationTransglycosylationTranspeptidation

Disease associations

Infection

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Antibiotic resistance

Interacting drugs

Penicillins

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