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Target intelligence / Profile preview
Penicillin-binding protein 2x
- Molecular classification
- Enzyme, Penicillin-Binding Protein
01
Overview
Penicillin-binding protein 2x (PBP2x) is a high-molecular-weight, membrane-associated enzyme found in *Streptococcus pneumoniae*. It plays a critical role in the final stages of peptidoglycan assembly, which is essential for bacterial cell wall synthesis and integrity. PBP2x is a transpeptidase that catalyzes the formation of peptide cross-links between adjacent glycan strands during cell wall peptidoglycan biosynthesis. It is a target for beta-lactam antibiotics, and mutations in pbpX encoding PBP2x are a mechanism by which *S. pneumoniae* develops resistance to these antibiotics.
- Other names
- PBP2xPBP-2X
02
Mechanism of action
Inhibition of transpeptidase activity via acylation of the active-site serine residue by beta-lactam antibiotics.
03
Biological functions
Cell wall peptidoglycan biosynthesisPeptide cross-linkingTranspeptidase activitySeptal cross-wall synthesisCell division
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Antibiotic resistance developmentMutations in pbpX leading to reduced antibiotic binding
06
Interacting drugs
Penicillins
2 more in the full profile.
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