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Penicillin-binding protein 5

Molecular classification: Enzyme, Penicillin-binding protein

Overview

Penicillin-binding protein 5 (PBP5) is an enzyme involved in bacterial cell wall synthesis and remodeling. It functions primarily as a D-alanyl-D-alanine carboxypeptidase, regulating peptidoglycan cross-linking. In some species, PBP5 also exhibits beta-lactamase activity or low affinity for beta-lactam antibiotics, contributing to antibiotic resistance. It is found in Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecium, making it clinically relevant in the context of drug-resistant infections.

Mechanism of action

Inhibition of peptidoglycan cross-linking; hydrolysis of beta-lactam antibiotics (in some species)

Biological functions

Peptidoglycan synthesisCell wall maintenanceD-alanyl-D-alanine carboxypeptidase activityBeta-lactamase activity (in some species)

Disease associations

InfectionAntibiotic resistance

Safety considerations

Antibiotic resistanceTherapeutic failure due to resistance

Interacting drugs

Penicillins

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