Penicillin-Binding Protein Transglycosylase Activity (PBP)

Penicillin-binding proteins (PBPs) are a group of enzymes crucial for bacterial cell wall synthesis. They possess transglycosylase activity, which polymerizes glycan chains, and transpeptidase activity, which cross-links peptide side chains, providing structural integrity to the bacterial cell wall. PBPs are the primary target for β-lactam antibiotics, which inhibit their activity, leading to bacterial lysis. Resistance can arise through mutations or acquisition of alternative PBPs. Some PBPs also act as sensors regulating antibiotic resistance mechanisms.

Other names

Penicillin-Binding ProteinsPBPsTransglycosylaseTranspeptidase

Inhibition of transglycosylase and transpeptidase activity, leading to disruption of peptidoglycan cross-linking and bacterial cell wall synthesis