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Penicillin G Acylase (PGA)
- Target
- PGA
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Penicillin G acylase (PGA) is an enzyme crucial in the industrial production of semi-synthetic β-lactam antibiotics. It catalyzes the hydrolysis of penicillin G into 6-aminopenicillanic acid (6-APA), a key building block for many common antibiotics like ampicillin and amoxicillin. It also hydrolyzes cephalosporin G. PGA is favored over chemical processes due to its efficiency and environmental benefits.
- Other names
- Penicillin G amidasePenicillin G amidohydrolaseBenzylpenicillin acylaseCephalosporin acylasePenicillin amidohydrolasePenicillin acylase
02
Mechanism of action
Hydrolyzes penicillin G to 6-amino penicillanic acid (6-APA) and phenylacetic acid.
03
Biological functions
Hydrolysis of penicillin GHydrolysis of cephalosporin GProduction of 6-amino penicillanic acid (6-APA)
04
Disease associations
Infection (indirectly, through antibiotic production)
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