Pentacyclic oxindole alkaloids (from Uncaria tomentosa and Uncaria guianensis) (POA)

Pentacyclic oxindole alkaloids are a group of bioactive compounds found primarily in the bark and root of the South American plants Uncaria tomentosa and Uncaria guianensis, commonly known as cat’s claw. These small-molecule plant alkaloids have been claimed to modulate the immune system by increasing white blood cell activity and elevating interleukin‑1 levels. Laboratory studies suggest they may also suppress pro-inflammatory cytokines such as TNF-alpha. Additional purported effects include antioxidant, anti-mutagenic, and anti-inflammatory actions through multiple pathways. While cat’s claw extracts containing these alkaloids are used traditionally for arthritis, digestive issues, viral infections, cancer prevention/treatment claims remain unproven. There is no evidence that pentacyclic oxindole alkaloids represent a single defined therapeutic target such as a receptor or enzyme; rather they act via broad immunomodulatory mechanisms on multiple cellular pathways.

Other names

Cat's claw alkaloidsUncaria tomentosa alkaloidsUña de gato alkaloids

Modulation of immune system by increasing white blood cell activity. Increase in interleukin‑1 levels. Suppression of pro-inflammatory cytokines such as TNF-alpha and others.