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Target intelligence / Profile preview
Pentameric glycoprotein H complex (Pentamer)
- Target
- Pentamer
- Molecular classification
- Glycoprotein complex, Viral protein complex
01
Overview
The Pentameric glycoprotein H complex (Pentamer) is a five-subunit protein assembly in Human Cytomegalovirus (HCMV) crucial for viral entry into epithelial, endothelial, and myeloid cells. Composed of gH, gL, UL128, UL130, and UL131A, it interacts with host cell receptors like neuropilin 2 (NRP2). The Pentamer determines viral tropism and modulates immediate early gene expression, influencing the balance between lytic replication and latency. It is a key target for neutralizing antibodies and vaccine development.
- Other names
- HCMV pentamergH/gL/UL128–131A complex
02
Mechanism of action
Neutralizing antibodies block cell entry by binding to the pentamer complex.
03
Biological functions
Cell entryTropism determinationTranscriptional regulationImmune evasionViral attachment
04
Disease associations
InfectionHuman Cytomegalovirus infectionViral pathogenesisLatency
05
Safety considerations
Targeting viral entry complexes may lead to the selection of resistant viral strains.Off-target effects due to sequence homology with host proteins.
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