Peptidase domain containing associated with muscle regeneration 1 (PAMR1)

Peptidase domain containing associated with muscle regeneration 1 (PAMR1) is a secreted protein that contains an inactive serine protease domain, CUB, EGF, and Sushi domains. It is thought to play a role in the regeneration of skeletal muscle, being induced upon muscle injury and downregulated in Duchenne muscular dystrophy. PAMR1 acts as a putative tumor suppressor; its expression is frequently suppressed in cancers, especially breast cancer, due to promoter hypermethylation. Restoration of PAMR1 expression suppresses tumor cell growth, and its methylation status is being investigated as a biomarker for cancer diagnosis and prognosis. Although it is structurally related to serine proteases, PAMR1 is predicted to lack enzymatic activity but may function in protein-protein interactions and modulation of growth factor signaling. No direct drugs are currently known to interact with PAMR1, but epigenetic drugs may indirectly affect its activity via demethylation

Other names

Regeneration-associated muscle protease homologInactive serine protease PAMR1RAMPFP938DKFZP586H2123Peptidase domain-containing protein associated with muscle regeneration 1

Demethylating agents: Reactivate silenced PAMR1 via promoter hypomethylation, potentially restoring tumor suppressor function. No known direct inhibitors or molecular-targeted drugs for PAMR1