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Target intelligence / Profile preview
Peptidase inhibitor 15 (PI15)
- Target
- PI15
- Molecular classification
- Protease inhibitor, Serine protease inhibitor, Cysteine-rich secretory protein (CRISP) family
01
Overview
Peptidase inhibitor 15 (PI15) is a serine peptidase/protease inhibitor with weak activity against trypsin, encoded by the PI15 gene on human chromosome 8[2][3][7][9]. It shares similarity with insect venom allergens, mammalian testis-specific proteins, and plant pathogenesis-related proteins[2][3]. It is notably expressed in neuroblastoma and glioblastoma cell lines, and it may play roles both in protease regulation and in development, such as facial patterning[2][3][4][9]. Emerging evidence suggests potential utility as a biomarker in cancers like cholangiocarcinoma[8].
- Other names
- CRISP8P24TIP25TI25 kDa trypsin inhibitorCysteine-rich secretory protein 8SugarCrispprotease inhibitor 15PI-15
02
Biological functions
Peptidase/protease inhibitionWeak inhibition of trypsinMay play a role in facial patterning during embryonic developmentPossible involvement in nervous system biology
03
Disease associations
NeuroblastomaHereditary breast ovarian cancer syndromeCholangiocarcinoma (as a marker)Other
04
Biomarkers
PI15 may be a novel marker for predicting diagnosis and follow-up of cholangiocarcinoma patients[8]
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