Peptide Aggregation

Peptide aggregation is the process by which individual peptide molecules associate to form larger assemblies through non-covalent and covalent interactions. This can result in amorphous aggregates, oligomers, or amyloid fibrils. Key drivers include hydrophobic interactions, hydrogen bonding, and electrostatic forces. Aggregation affects the stability and efficacy of therapeutic peptides, potentially leading to toxicity and immunogenicity. In biological systems, it is implicated in diseases like Alzheimer's and Parkinson's. It also presents challenges during peptide synthesis.

Other names

Protein Aggregation (when referring to aggregation of proteins)Peptide Self-Assembly