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Peptide bond cleavage at the carboxyl side of lysine or arginine residues

Molecular classification: Peptide bond, Proteolysis site

Overview

The peptide bond at the carboxyl side of lysine or arginine residues is a specific site within a protein's primary structure. It represents the amide linkage immediately following either a lysine (Lys, K) or arginine (Arg, R) residue, connecting its carboxyl group to the amino group of the next amino acid in sequence. This site is targeted by proteolytic enzymes, most notably trypsin, for selective hydrolysis. It plays a crucial role in protein digestion, processing, and turnover. While not a therapeutic target itself, it is essential for enzymatic processing in biology and analytical workflows.

Biological functions

Protein digestionProtein processingProteolysis

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