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Target intelligence / Profile preview
Peptide-chain-release factor 3 (RF3)
- Target
- RF3
- Molecular classification
- Enzyme, GTPase, Class II polypeptide chain release factor, Translational GTPase
01
Overview
Peptide-chain-release factor 3 (RF3) is a GTPase enzyme found in a broad range of bacteria. It plays an essential role in the termination phase of protein synthesis by facilitating the recycling and removal of class I release factors (RF1 and RF2) from the ribosome after peptide release. RF3 also contributes to quality control during translation. It can stimulate premature termination on aberrant peptides, thereby enhancing fidelity by preventing accumulation of faulty proteins.
- Other names
- Release factor 3prfC gene product
02
Mechanism of action
Not applicable, as it's a target for potential inhibition, not a drug itself. Potential mechanisms involve disrupting GTP binding/hydrolysis or interfering with RF1/RF2 interaction.
03
Biological functions
Translation terminationRecycling of class I release factorsQuality control during protein synthesisRibosome recycling
04
Disease associations
Infection
05
Safety considerations
Inhibition may disrupt essential bacterial protein synthesis, leading to potential toxicity. Selectivity for bacterial RF3 over eukaryotic counterparts is critical.
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