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Peptide Deformylase (PDF)

Target: PDF
Molecular classification: Enzyme, Metalloenzyme, Hydrolase

Overview

Peptide deformylase (PDF) is a metalloenzyme that catalyzes the removal of the formyl group from the N-terminus of nascent polypeptide chains in bacteria, mitochondria, and chloroplasts. It is essential for protein maturation and bacterial viability, making it an attractive target for antibacterial drug development. Inhibitors like actinonin bind to its active site.

Mechanism of action

Peptide deformylase inhibitors bind to the enzyme's active site, preventing the removal of the formyl group from nascent polypeptide chains, leading to accumulation of non-functional proteins.

Biological functions

Protein maturationFormyl group removalProtein processingCatalysis

Disease associations

Infection

Safety considerations

Inhibition can disrupt bacterial protein synthesis.Potential for off-target effects on mitochondrial protein synthesis in eukaryotes.

Interacting drugs

Actinonin

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