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Peptide Elongation Factor 2 (eEF2)

Target: eEF2
Molecular classification: GTP-binding protein, Enzyme

Overview

Peptide elongation factor 2 (eEF2) is an essential GTP-binding protein involved in the process of protein synthesis in eukaryotic and archaeal cells. It catalyzes the GTP-dependent translocation step during mRNA translation, promoting the movement of ribosomes along mRNA after peptide bond formation. Its activity is tightly regulated by phosphorylation, and it is targeted by bacterial toxins like diphtheria toxin and exotoxin A, which inhibit its function and lead to cell death.

Mechanism of action

ADP-ribosylation of diphthamide residue, leading to inhibition of protein synthesis.

Biological functions

mRNA translationRibosomal translocationProtein synthesis

Disease associations

CancerInfectionOther

Safety considerations

Inhibition leads to cessation of cellular protein productionADP-ribosylation by toxins leads to cell death

Interacting drugs

Diphtheria toxin

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