Peptide Tyrosine-Tyrosine Receptor Family (PYY Receptor Family)

The Peptide Tyrosine-Tyrosine (PYY) receptor family primarily refers to the neuropeptide Y (NPY) receptor family, which includes Y1, Y2, Y4, and Y5 receptor subtypes. These are G-protein-coupled receptors that bind PYY, a gut-derived hormone involved in appetite regulation. PYY3-36 is the predominant circulating form and primarily binds to the Y2 receptor, suppressing appetite and modulating gastrointestinal motility. Modulators targeting these receptors, especially the Y2 receptor, are under investigation for obesity treatment.

Other names

Peptide YY ReceptorNPY Receptor FamilyNeuropeptide Y Receptor Family

Agonists or antagonists of NPY receptor subtypes (Y1, Y2, Y4, Y5). Primarily Y2 receptor modulation to regulate appetite and gastrointestinal function.