Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Peptidoglycan Cell Wall Precursor D-Alanyl-D-Alanine Terminus (D-Ala-D-Ala terminus)
- Target
- D-Ala-D-Ala terminus
- Molecular classification
- Peptide, Cell Wall Component
01
Overview
The D-alanyl-D-alanine (D-Ala-D-Ala) terminus is a dipeptide motif found at the end of the peptide side chains in peptidoglycan precursors. It is essential for cross-linking during peptidoglycan biosynthesis and is a target for glycopeptide and β-lactam antibiotics. Resistance can arise from alterations to this terminus.
- Other names
- D-Ala-D-Ala(R)-2-((R)-2-Aminopropanamido)propanoic acidD-alanyl-D-alanine
02
Mechanism of action
Vancomycin binds directly to the D-Ala-D-Ala terminus, blocking transglycosylation and transpeptidation. β-lactams mimic the D-Ala-D-Ala terminus and inhibit transpeptidases.
03
Biological functions
Peptidoglycan biosynthesisCell wall synthesisSubstrate for transpeptidasesCell wall cross-linking
04
Disease associations
InfectionBacterial resistance
05
Safety considerations
Antibiotic resistanceAlteration of target structure leading to resistance
06
Interacting drugs
Vancomycin
3 more in the full profile.
Beyond the preview
Go deeper on Peptidoglycan Cell Wall Precursor D-Alanyl-D-Alanine Terminus (D-Ala-D-Ala terminus).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Peptidoglycan Cell Wall Precursor D-Alanyl-D-Alanine Terminus (D-Ala-D-Ala terminus).