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Peptidoglycan Precursor (acyl-D-ala-D-ala) (acyl-D-Ala-D-Ala)
- Target
- acyl-D-Ala-D-Ala
- Molecular classification
- Peptide, Dipeptide, Peptidoglycan Precursor
01
Overview
The peptidoglycan precursor containing the acyl-D-alanyl-D-alanine (D-Ala-D-Ala) motif is a critical building block in bacterial cell wall biosynthesis. This dipeptide is essential for cross-linking glycan strands during cell wall synthesis and is the target of several classes of antibiotics, including β-lactams and glycopeptides. Alterations to this motif are a key mechanism of antibiotic resistance.
- Other names
- D-alanyl-D-alanineD-Ala-D-AlaD-Alanine, D-alanyl-(R)-2-((R)-2-Aminopropanamido)propanoic acidTerminal pentapeptide
02
Mechanism of action
β-lactams mimic D-Ala-D-Ala, binding to transpeptidases and inhibiting cross-linking. Glycopeptides bind to D-Ala-D-Ala, blocking polymerization and cross-linking.
03
Biological functions
Cell wall biosynthesisSubstrate for transpeptidation/crosslinkingBacterial cell wall assembly
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Antibiotic resistance developmentAlterations or replacements at the D-Ala-D-Ala site are key mechanisms for glycopeptide resistance
06
Interacting drugs
β-lactam antibiotics
2 more in the full profile.
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