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Peptidoglycan Precursor (D-Ala-D-Ala Terminus) (D-Ala-D-Ala terminus)
- Target
- D-Ala-D-Ala terminus
- Molecular classification
- Peptide, Peptidoglycan component
01
Overview
The peptidoglycan precursor with a D-Ala-D-Ala terminus is a key structural and functional motif in bacterial cell wall biosynthesis. It refers specifically to the terminal dipeptide sequence—D-alanyl-D-alanine—found at the end of the peptide stem attached to N-acetylmuramic acid (MurNAc) residues within peptidoglycan precursors, such as Lipid II. It is essential for cross-linking during cell wall synthesis and is a target for several antibiotics.
- Other names
- D-Alanyl-D-Alanine terminusPeptidoglycan D-Ala-D-AlaMurNAc-pentapeptide (D-Ala-D-Ala terminus)Lipid II (D-Ala-D-Ala terminus)
02
Mechanism of action
Vancomycin binds to D-Ala-D-Ala, blocking transglycosylation and transpeptidation. β-lactams inhibit penicillin-binding proteins.
03
Biological functions
Cell wall biosynthesisSubstrate for transpeptidationCross-linking of peptidoglycanStructural component of bacterial cell wall
04
Disease associations
Bacterial infection
05
Safety considerations
Development of antibiotic resistance (e.g., D-Ala-D-Lac substitution)
06
Interacting drugs
Vancomycin
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