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Peptidoglycan Precursor D-Ala-D-Ala Motif (D-Ala-D-Ala)
- Target
- D-Ala-D-Ala
- Molecular classification
- Peptide, Peptidoglycan precursor component
01
Overview
The D-Ala-D-Ala motif refers to a dipeptide composed of two D-alanine residues. This motif is a critical component of the peptide stem in bacterial peptidoglycan precursors. The presence and structure of this motif are essential for proper cross-linking during cell wall biosynthesis in bacteria and serves as a target for antibiotics.
- Other names
- D-alanyl-D-alanineD-Ala-D-Ala terminusD-Ala-D-Ala dipeptide
02
Mechanism of action
β-lactam antibiotics inhibit transpeptidases by mimicking D-Ala-D-Ala. Glycopeptides bind to D-Ala-D-Ala, blocking transpeptidase access.
03
Biological functions
Substrate for transpeptidasesCell wall biosynthesisCross-linking of peptidoglycanBacterial cell wall integrity
04
Disease associations
Bacterial infection
05
Interacting drugs
Penicillins
3 more in the full profile.
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