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Peptidoglycan Precursor D-Ala-D-Ala Terminus (D-Ala-D-Ala Terminus)
- Target
- D-Ala-D-Ala Terminus
- Molecular classification
- Peptide, Cell Wall Component
01
Overview
The D-Ala-D-Ala terminus is a critical structural motif found at the end of the peptide stem in peptidoglycan precursors. It's essential for bacterial cell wall synthesis and a key target for antibiotics like vancomycin and β-lactams. Resistance can arise through modifications like D-Ala-D-Lac substitution.
- Other names
- D-alanyl-D-alaninePeptidoglycan pentapeptide terminusLipid II precursor terminus
02
Mechanism of action
Vancomycin binds directly to the D-Ala-D-Ala dipeptide, blocking transglycosylation and transpeptidation. β-lactams mimic D-Ala-D-Ala, inhibiting penicillin-binding proteins.
03
Biological functions
Cell wall synthesisTranspeptidation substrateCross-linking of peptidoglycanStructural component of peptidoglycan
04
Disease associations
Bacterial infection
05
Safety considerations
Antibiotic resistanceEmergence of vancomycin-resistant bacteria
06
Interacting drugs
Vancomycin
1 more in the full profile.
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