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Target intelligence / Profile preview
Peptidyl Arginine Deiminase 2 (PADI2)
- Target
- PADI2
- Molecular classification
- Enzyme, Peptidyl arginine deiminase
01
Overview
Peptidyl arginine deiminase 2 (PADI2) is an enzyme that catalyzes the conversion of protein-bound arginine residues into citrulline. It requires calcium ions for enzymatic activity and is involved in myelination, immune regulation, and gene expression. PADI2 is implicated in diseases like multiple sclerosis, rheumatoid arthritis, and cancer, making it a potential drug target.
- Other names
- PAD-H19PAD2PDI2
02
Mechanism of action
Inhibition of PADI2 enzymatic activity, preventing citrullination of target proteins.
03
Biological functions
MyelinationImmune regulationGene expression modulationArginine to Citrulline conversion on proteins
04
Disease associations
Multiple sclerosisRheumatoid arthritisNeurodegenerative disordersCancerGlaucomaInflammation
05
Safety considerations
Potential for off-target effects on other PAD isoformsImpact on immune homeostasis if PADI2 inhibition is too broad.
06
Interacting drugs
Small-molecule inhibitors of PADI2 (experimental and preclinical)
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