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Target intelligence / Profile preview
Peptidyl Arginine Deiminase 4 (PAD4)
- Target
- PAD4
- Molecular classification
- Enzyme, Protein-arginine deiminase family, Histone modification
01
Overview
Peptidyl arginine deiminase 4 (PAD4) is an enzyme that catalyzes the conversion of arginine residues in proteins to citrulline. It plays critical roles in gene regulation, immune response, and disease pathogenesis, particularly in histone modification, neutrophil extracellular trap formation, and autoimmune diseases. PAD4 is a promising therapeutic target for a range of diseases due to its involvement in inflammation and epigenetic regulation.
- Other names
- PADI4PADPADI5PDI4PDI5
02
Mechanism of action
Small-molecule inhibitors of PAD4 are under investigation.
03
Biological functions
Histone modificationEpigenetic regulationNeutrophil extracellular trap (NET) formationImmune responseChromatin decondensationGene expression regulation
04
Disease associations
Autoimmune diseases (e.g., Rheumatoid Arthritis)Cardiovascular diseasesCancerInflammation
05
Safety considerations
Potential for immunosuppressionOff-target effects on other PAD family membersDisruption of NET formation leading to increased susceptibility to infectionUnintended alterations in chromatin structure and gene expression
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