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Target intelligence / Profile preview
Cyclophilin (Cyp)
- Target
- Cyp
- Molecular classification
- Immunophilin, Enzyme, Peptidyl-prolyl cis-trans isomerase (PPIase), Chaperone
01
Overview
Cyclophilins are a family of immunophilins characterized by peptidyl-prolyl cis-trans isomerase (PPIase) activity, crucial for protein folding and chaperone activity. Cyclophilin A (CypA) is the main target of cyclosporin A, mediating immunosuppression by inhibiting calcineurin. Cyclophilins are also involved in viral replication, making them potential antiviral targets.
- Other names
- ImmunophilinPeptidyl-prolyl cis-trans isomerase
02
Mechanism of action
Cyclosporin A binds to cyclophilin, and the resulting complex inhibits calcineurin, preventing T-cell activation. Inhibition of peptidyl-prolyl cis-trans isomerase (PPIase) activity.
03
Biological functions
Protein foldingSignal transductionImmunomodulationChaperone activityViral replication
04
Disease associations
Autoimmune diseasesViral infectionsOrgan transplant rejection
05
Safety considerations
Immunosuppression related side effects (e.g., increased risk of infection, malignancy)Nephrotoxicity
06
Interacting drugs
Cyclosporin A
1 more in the full profile.
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