Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Peptidyl-prolyl cis-trans isomerase A-like 4C (PPIAL4C)
- Target
- PPIAL4C
- Molecular classification
- Enzyme, peptidyl-prolyl cis-trans isomerase, molecular chaperones, cyclophilins
01
Overview
Peptidyl-prolyl cis-trans isomerase A-like 4C (PPIAL4C) is a member of the cyclophilin family of enzymes that catalyze the cis-trans isomerization of proline residues in peptide chains, facilitating efficient and accurate protein folding within the cell. PPIAL4C is a protein-coding gene located on chromosome 1. While direct functional data are scarce, it is predicted to display cyclosporin A binding and peptidyl-prolyl cis-trans isomerase activity, and it may be involved in regulating protein folding and function. Diseases associated with PPIAL4C include well-differentiated liposarcoma and Glycogen Storage Disease III. As an enzyme, PPIAL4C fits within the broader category of cyclophilins, which are implicated in cellular signaling, apoptosis, inflammation, and cancer biology through their impact on protein folding and isomerization[3][9][11][5].
- Other names
- Peptidyl-prolyl cis-trans isomerase A-like 4CPPIAL4CPPIase A-like 4CCOAS-2Chromosome 1-amplified sequence 2Cyclophilin homolog overexpressed in liver cancerPeptidylprolyl isomerase A (cyclophilin A)-like 4C
02
Mechanism of action
Inhibition of isomerase activity
03
Biological functions
Protein foldingProtein isomerizationMay regulate cell signaling and protein-protein interactions
04
Disease associations
Cancerwell-differentiated liposarcomaGlycogen Storage Disease III
05
Interacting drugs
Cyclosporin A
Beyond the preview
Go deeper on Peptidyl-prolyl cis-trans isomerase A-like 4C (PPIAL4C).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Peptidyl-prolyl cis-trans isomerase A-like 4C (PPIAL4C).