Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Peptidyl-prolyl cis-trans isomerase A-like 4E (PPIAL4E)
- Target
- PPIAL4E
- Molecular classification
- Enzyme, Peptidyl-prolyl cis-trans isomerase family (PPIase), Cyclophilin-like protein
01
Overview
Peptidyl-prolyl cis-trans isomerase A-like 4E (PPIAL4E) is a predicted cyclophilin-like protein, part of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which modulates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds. Its function is deduced mainly from studies of the well-characterized Cyclophilin A (PPIA), which plays roles in intracellular signaling, transcription, inflammation, apoptosis, and cell proliferation. PPIAL4E is predicted to have similar enzymatic activity and is active in the cytoplasm. No direct evidence defines its biological function or disease relevance; most roles are extrapolated from PPIase family data. As such, PPIAL4E is not considered a canonical drug target, has no established interacting drugs or mechanisms, and is not used as a clinical biomarker. Further research is required to confirm its functional and disease-related significance.
- Other names
- PPIAL4FCOAS2Peptidylprolyl isomerase A (cyclophilin A)-like 4E
02
Mechanism of action
No specific inhibitors or mechanisms known for PPIAL4E
03
Biological functions
Protein folding (predicted)Cellular signaling modulation (by analogy to Cyclophilin A)Possibly involved in cellular responses to stress (hypoxia, angiogenesis, inferred from PPIA/CD147 studies, not directly shown for PPIAL4E)
04
Disease associations
Tumor progression (inferred from cyclophilin A function and its receptor CD147 in squamous cell carcinoma, but not directly demonstrated for PPIAL4E)Other (no direct clinical associations reported for PPIAL4E; extrapolated possible cancer relevance based on family members)
Beyond the preview
Go deeper on Peptidyl-prolyl cis-trans isomerase A-like 4E (PPIAL4E).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Peptidyl-prolyl cis-trans isomerase A-like 4E (PPIAL4E).