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Peptidyl-prolyl cis-trans isomerase A-like 4F (PPIAL4F)

Target: PPIAL4F
Molecular classification: Enzyme (peptidyl-prolyl cis-trans isomerase, based on homology[7][9]), Other (cyclophilin family member; unclear/possible pseudogene)

Overview

Peptidyl-prolyl cis-trans isomerase A-like 4F (PPIAL4F) is a predicted human protein and paralog of peptidyl-prolyl isomerase A (PPIA, cyclophilin A), but its function has not been experimentally verified. Based on sequence similarity, it is believed to belong to the cyclophilin family of peptidyl-prolyl cis-trans isomerases, which catalyze the cis-trans isomerization of proline residues in polypeptides and promote protein folding. However, PPIAL4F has been described in some databases as a pseudogene or as having uncertain protein-coding potential[5][7][9]. There is no known evidence that PPIAL4F is an active enzyme or therapeutically tractable target; it is not implicated in any specific biological function or disease, and no drug interactions or biomarker utility are reported.

Other names: PPIAL4FPeptidylprolyl isomerase A like 4FPeptidyl-prolyl cis-trans isomerase A-like 4FCyclophilin-LC (COAS2) pseudogenePeptidylprolyl isomerase A (cyclophilin A)-like 4FPPIase A-like 4F

Biological functions

Protein folding (predicted, by similarity to other cyclophilins[7][9])Cis-trans isomerization of proline bonds in oligopeptides (predicted[7][9])Other (no direct functional data available for this specific isoform; annotation by similarity)

Disease associations

Other (not directly implicated in disease; only a gene association with Chromosome 1q21.1 deletion syndrome is listed[7], which is unlikely to be a direct or causal role)

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