Peptidyl-prolyl cis-trans isomerase A-like 4H (PPIAL4H)

Peptidyl-prolyl cis-trans isomerase A-like 4H (PPIAL4H) is a predicted enzyme of the cyclophilin family whose main attributed biochemical activities—based on sequence similarity—are the isomerization of proline imidic peptide bonds in oligopeptides and potential involvement in protein folding processes[7][8]. It is predicted to bind cyclosporin A and act within the cytoplasm, but there are no experimentally validated biological roles, disease associations, or known small molecule interactors, and it is not recognized as a therapeutic target[7][8]. Functional information, disease associations, and clinical relevance remain uncharacterized, and understanding of this gene product is limited largely to computational prediction. Clarifications: - PPIAL4H is a protein-coding gene with close paralogs like PPIAL4C but does not correspond to a well-characterized protein target, receptor, or enzyme in human physiology or therapeutics[7][8]. - There is no evidence that this is considered a therapeutic target or that it has validated roles in human disease. - No drugs, mechanisms of action, biomarker associations, or safety issues are documented. - The entry is likely a predicted or poorly characterized paralog of better-known cyclophilins such as cyclophilin A (PPIA), but has not been functionally described or validated[7][8]. - The Ensembl gene ID is ENSG00000270339[6]. Note: This entry is best classified as not a well-recognized or validated target, and most fields are returned as null or with "predicted" due to the absence of experimental confirmation or therapeutic relevance.

Other names

Peptidylprolyl isomerase A like 4HPPIase A-like 4HPAL4H