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Target intelligence / Profile preview
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)
- Target
- FKBP1A
- Molecular classification
- Enzyme, Peptidyl-prolyl cis-trans isomerase, Immunophilin
01
Overview
Peptidyl-prolyl cis-trans isomerase FKBP1A, also known as FKBP12, is a member of the immunophilin protein family. It functions primarily as a peptidyl-prolyl cis-trans isomerase (PPIase), catalyzing the interconversion between cis and trans forms of proline imidic peptide bonds in oligopeptides, thereby accelerating protein folding. It binds immunosuppressive drugs such as tacrolimus (FK506) and sirolimus (rapamycin), and regulates intracellular signaling.
- Other names
- FKBP12Calstabin-1RotamaseImmunophilin FKBP12
02
Mechanism of action
Inhibition of calcineurin or mTOR pathways through formation of drug-protein complexes
03
Biological functions
Protein folding/maturationRegulation of TGF-beta/activin signalingCalcium channel modulationCis-trans isomerization of proline residues
04
Disease associations
Congenital heart disordersNoncompaction of left ventricular myocardium
05
Safety considerations
ImmunosuppressionPotential for congenital heart disorders (based on mouse homolog studies)
06
Interacting drugs
Tacrolimus (FK506)
1 more in the full profile.
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