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Target intelligence / Profile preview
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)
- Target
- FKBP4
- Molecular classification
- Enzyme, PPIase, FKBP
01
Overview
Peptidyl-prolyl cis-trans isomerase FKBP4, also known as FKBP52, is a member of the FK506-binding protein (FKBP) subfamily within the broader peptidyl-prolyl cis/trans isomerases (PPIases) enzyme family. These enzymes catalyze the interconversion between the cis and trans forms of peptide bonds at proline residues in polypeptides—a critical step for proper protein folding and function. FKBP4 also acts as a co-chaperone for steroid receptors and interacts with immunosuppressive drugs such as tacrolimus (FK506).
- Other names
- FKBP52FKBP-52Prolyl Isomerase 4Peptidylprolyl Isomerase 4FK506 binding protein 52
02
Mechanism of action
Inhibition of peptidyl-prolyl cis-trans isomerase activity
03
Biological functions
Protein foldingChaperone activityImmune modulationHormone receptor regulation
04
Disease associations
CancerNeurodegenerative diseaseViral infectionInflammation
05
Interacting drugs
Tacrolimus (FK506)
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