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Target intelligence / Profile preview
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)
- Target
- PIN1
- Molecular classification
- Enzyme, Peptidyl-prolyl cis/trans isomerase (PPIase), Rotamase
01
Overview
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is an enzyme that catalyzes the cis-trans isomerization of specific pSer/Thr-Pro motifs within target proteins, modulating their conformation, function, and stability. It plays a role in cell cycle regulation, signal transduction, and metabolism. PIN1 is implicated in diseases such as cancer and Alzheimer's disease, making it a potential therapeutic target.
- Other names
- Peptidyl-prolyl cis/trans isomerase Pin1PPIase Pin-1Rotamase Pin1
02
Mechanism of action
Inhibition of PIN1 activity
03
Biological functions
Cell cycle regulationSignal transductionProtein foldingAdipogenesisMetabolism
04
Disease associations
CancerAlzheimer’s DiseaseObesityDiabetes
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