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Peptidyl Transferase
- Molecular classification
- Ribozyme, Enzyme
01
Overview
Peptidyl transferase is a ribozyme located in the large subunit of the ribosome that catalyzes peptide bond formation during protein synthesis and peptidyl-tRNA hydrolysis during translation termination. The catalytic activity is performed entirely by ribosomal RNA (rRNA), specifically the 23S rRNA in prokaryotes and the 28S rRNA in eukaryotes. Many antibiotics target this center to inhibit bacterial protein synthesis.
02
Mechanism of action
Inhibition of peptide bond formation by binding to the peptidyl transferase center (PTC) of the ribosome, thereby disrupting protein synthesis.
03
Biological functions
Peptide bond formationPeptidyl-tRNA hydrolysisProtein biosynthesisTranslation
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistanceSpecies-specific binding variations
06
Interacting drugs
Antibiotics (e.g., Chloramphenicol, Erythromycin, Tetracycline, Clindamycin)
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