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Peptidyl Transferase (23S rRNA of 50S Ribosomal Subunit) (PTC)
- Target
- PTC
- Molecular classification
- Ribozyme, rRNA, Enzyme
01
Overview
Peptidyl transferase is the catalytic activity located within the 23S ribosomal RNA (rRNA) of the large (50S) subunit of prokaryotic ribosomes. It catalyzes peptide bond formation between amino acids during protein synthesis, a central step in translation. The peptidyl transferase center (PTC), formed primarily by domain V of 23S rRNA, acts as a ribozyme. Many antibiotics target the PTC/23S rRNA to inhibit bacterial protein synthesis.
- Other names
- Peptidyl Transferase Center23S rRNARibosomal Peptidyl Transferase
02
Mechanism of action
Inhibition of peptide bond formation
03
Biological functions
Peptide bond formationProtein synthesisTranslation
04
Disease associations
Infection
05
Safety considerations
Off-target effects on mitochondrial ribosomesAntibiotic resistance
06
Interacting drugs
Macrolides
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