Target intelligence / Profile preview

Peptidyl Transferase (Large Ribosomal Subunit) (PTC)

Target: PTC
Molecular classification: Ribozyme, RNA enzyme

Overview

Peptidyl transferase is a ribozyme located in the large subunit of the ribosome. It catalyzes two essential reactions during protein synthesis: formation of peptide bonds between adjacent amino acids and hydrolysis of peptidyl-tRNA, releasing the completed polypeptide chain at translation termination. The catalytic center (PTC) is composed entirely of rRNA. Many antibiotics target this center to inhibit bacterial protein synthesis.

Mechanism of action

Inhibition of bacterial protein synthesis by binding to the peptidyl transferase center.

Biological functions

Peptide bond formationHydrolysis of peptidyl-tRNAProtein synthesis

Disease associations

Infection

Safety considerations

Antibiotic resistance

Interacting drugs

Antibiotics (various)

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