Target intelligence / Profile preview

Peptidyl Transferase Activity (23S rRNA) (PTC)

Target: PTC
Molecular classification: Ribozyme, RNA, Enzyme

Overview

Peptidyl transferase activity refers to the ribozyme function of the large ribosomal subunit, specifically catalyzed by 23S ribosomal RNA (rRNA) in prokaryotes. This activity is central to protein synthesis, as it forms peptide bonds between amino acids during translation. It is a key target for several antibiotics.

Other names: Peptidyl Transferase Center23S rRNA peptidyl transferaseRibosomal peptidyl transferase

Mechanism of action

Inhibition of peptide bond formation/translocation

Biological functions

Peptide bond formationPeptidyl-tRNA hydrolysisProtein synthesisTranslation

Disease associations

Infection

Safety considerations

Antibiotic resistance

Interacting drugs

Chloramphenicol

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