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Peptidyl transferase activity (of ribosome) (PTC)
- Target
- PTC
- Molecular classification
- Ribozyme, rRNA, Enzyme
01
Overview
The peptidyl transferase activity is a fundamental enzymatic function of the ribosome, responsible for catalyzing peptide bond formation during protein synthesis. This activity occurs at a specialized region known as the peptidyl transferase center (PTC), which is located in the large subunit of both prokaryotic and eukaryotic ribosomes. The PTC is an RNA-based enzyme (ribozyme), not a protein enzyme. Its catalytic function is carried out entirely by ribosomal RNA (rRNA). It is a crucial target for many antibiotics.
- Other names
- Peptidyl transferase centerRibosomal peptidyl transferase23S rRNA peptidyl transferase (prokaryotes)28S rRNA peptidyl transferase (eukaryotes)
02
Mechanism of action
Inhibition of peptide bond formation; disruption of ribosomal function
03
Biological functions
Peptide bond formationProtein biosynthesisTranslation terminationHydrolysis of peptidyl-tRNA
04
Disease associations
Infection
05
Safety considerations
Off-target effects on mitochondrial ribosomes (for some inhibitors)Potential for disruption of protein synthesis in host cells
06
Interacting drugs
Anisomycin
2 more in the full profile.
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