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Target intelligence / Profile preview
Peptidyltransferase (Bacterial Ribosome) (PTC)
- Target
- PTC
- Molecular classification
- Ribozyme, rRNA, Enzyme
01
Overview
The peptidyltransferase center within bacterial ribosomes is an ancient RNA-based catalyst essential for life. It orchestrates both elongation and termination phases during translation through precise alignment and activation of substrates—functions targeted by several major classes of antibiotics. Its structure-function relationships continue to be central topics in molecular biology research due to their implications for evolution, medicine, and biotechnology.
- Other names
- Peptidyl transferase center23S rRNA peptidyltransferase
02
Mechanism of action
Inhibition of peptide bond formation or polypeptide release by binding to the peptidyl transferase center on the 23S rRNA of the bacterial ribosome.
03
Biological functions
Peptide bond formationPolypeptide chain elongationPeptide releaseTranslation
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistance due to mutations in 23S rRNA or modifications affecting drug binding.Off-target effects on mitochondrial ribosomes (structural similarity)
06
Interacting drugs
Chloramphenicol
4 more in the full profile.
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