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Peptidyl Transferase Center of 23S rRNA (PTC)
- Target
- PTC
- Molecular classification
- Ribozyme, rRNA
01
Overview
The peptidyl transferase center (PTC) is a highly conserved functional region within the 23S ribosomal RNA (rRNA) of the large ribosomal subunit in prokaryotes. It acts as an aminoacyltransferase ribozyme, catalyzing peptide bond formation between adjacent amino acids during protein synthesis. The PTC is also responsible for peptidyl-tRNA hydrolysis, which releases the newly synthesized polypeptide chain at the end of translation. Many antibiotics inhibit bacterial protein synthesis by binding directly to or near this center, blocking peptide bond formation or stalling ribosome movement on mRNAs.
02
Mechanism of action
Inhibition of peptide bond formation; Stalling ribosome movement
03
Biological functions
Peptide bond formationPeptidyl-tRNA hydrolysisAminoacyltransferase activityTranslation
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistance due to mutations in the PTCOff-target effects of antibiotics
06
Interacting drugs
Antibiotics (e.g., Chloramphenicol, Macrolides, Lincosamides)
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