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Target intelligence / Profile preview
Peptidylarginine deiminase 1 (PADI1)
- Target
- PADI1
- Molecular classification
- Enzyme
01
Overview
Peptidylarginine deiminase 1 (PADI1) is an enzyme that catalyzes the conversion of arginine residues in proteins to citrulline residues, a process known as deimination or citrullination. It plays a crucial role in skin physiology, particularly in epidermal differentiation and maintaining the cutaneous barrier function. Dysregulation of PADI1 is implicated in various autoimmune diseases and cancers, making it a potential therapeutic target.
- Other names
- PAD1HPAD10PDIPDI1
02
Mechanism of action
Pharmacological inhibition of PADI1
03
Biological functions
Post-translational modification (deimination/citrullination)Skin barrier maintenanceRegulation of tissue hydration
04
Disease associations
Rheumatoid arthritisAlzheimer's diseaseMultiple sclerosisLupusParkinson's diseaseCancerInflammatory disorders
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