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Target intelligence / Profile preview
Peptidylarginine Deiminase 3 (PADI3)
- Target
- PADI3
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Peptidylarginine deiminase 3 (PADI3) is an enzyme that catalyzes the post-translational conversion of arginine residues in proteins into citrullines (deimination). It is primarily expressed in the skin and hair follicles, where it modifies structural proteins like filaggrin and trichohyalin, contributing to hair follicle formation and epidermal cell differentiation. Mutations in PADI3 are associated with uncombable hair syndrome.
- Other names
- PAD3PDI3UHS1Peptidyl arginine deiminase type III
02
Mechanism of action
Catalyzes the conversion of protein-bound arginine to protein-bound citrulline, using calcium ions.
03
Biological functions
CitrullinationDeiminationPost-translational modificationHair follicle formationEpidermal cell differentiation
04
Disease associations
Uncombable Hair SyndromeCentral Centrifugal Cicatricial Alopecia
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