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Peptidylprolyl isomerase A-like 4A pseudogene (PPIAL4A)

Target: PPIAL4A
Molecular classification: Pseudogene, Long non-coding RNA (lncRNA) related (by homology/family to cyclophilin proteins, specifically the cyclophilin A family)

Overview

PPIAL4A (Peptidylprolyl isomerase A-like 4A pseudogene) is a human pseudogene resembling the peptidylprolyl isomerase A (PPIA) gene. While PPIA encodes Cyclophilin A, a well-known protein involved in protein folding and immunosuppression (as a cyclosporine target), PPIAL4A does not encode a functional protein and is categorized as a long non-coding RNA. PPIAL4A may play a role in the posttranscriptional regulation of its parental gene by acting as a decoy for microRNAs and potentially influencing expression of PPIA and other cyclophilin-related genes. However, no evidence suggests it is a direct therapeutic target, nor is it associated with approved drugs or established in disease mechanisms beyond speculative regulatory roles[2][1].

Other names: Peptidylprolyl isomerase A-like 4APPIAL4A pseudogene

Biological functions

Possible regulatory role in gene expression as a competing endogenous RNA (ceRNA), by sponging microRNAs that would otherwise act on related protein-coding genes, e.g. PPIAMay impact protein folding indirectly by modulating the expression of parental gene PPIA

Disease associations

No direct evidence of involvement in disease as a protein targetPotential indirect association with cancer or inflammation via effects on PPIA expression and/or miRNA regulation; this is inferred from studies of other PPIA pseudogenes, but not specifically PPIAL4A

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