Peptidylprolyl isomerase A pseudogene

Peptidylprolyl isomerase A pseudogene refers to one of multiple genomic loci that resemble the protein-coding gene for peptidylprolyl isomerase A (PPIA, cyclophilin A), but do not encode functional protein; these pseudogenes may be transcribed as long non-coding RNAs and are implicated in post-transcriptional gene regulation, primarily by acting as competitive endogenous RNAs (ceRNAs) that modulate the availability or function of microRNAs and affect the expression of the parental PPIA gene[2][3][6]. For example, the peptidylprolyl isomerase A pseudogene 22 (PPIAP22) has been reported to upregulate PPIA expression by sponging miR-197-3p, impacting hepatocellular carcinoma progression, tumor immunity, and mRNA processing[2][3][6]. However, pseudogenes, including ENSG00000229595 (peptidylprolyl isomerase A pseudogene), are not themselves therapeutic targets, receptors, enzymes, or druggable entities in current biomedical practice. The term "peptidylprolyl isomerase A pseudogene" describes a genomic element with regulatory rather than protein-coding or drug-interactable function. Key context: - This entry refers to a pseudogene, not a typical therapeutic target. - The gene is not coding for a functional protein and is not amenable to direct pharmacological modulation. - It may have indirect relevance in disease via gene regulatory mechanisms in cancer, especially as part of ceRNA networks. - ENSG00000229595 is likely one of several annotated peptidylprolyl isomerase A pseudogenes—careful distinction from the parental PPIA gene (cyclophilin A) is essential[2][3][6]. - For standard therapeutic target information (druggable, protein-coding, mechanistically defined), see the parental gene peptidylprolyl isomerase A (PPIA, cyclophilin A)[1][4]. This entry is not a therapeutic target, but may be of research interest in gene regulatory studies in cancer.

Other names

Peptidylprolyl isomerase A pseudogenePPIA pseudogene