Peptidylprolyl isomerase A pseudogene 20 (PPIAP20)

Peptidylprolyl isomerase A pseudogene 20 (PPIAP20) is a non-protein-coding pseudogene homologous to the gene encoding cyclophilin A (PPIA), an enzyme with peptidyl-prolyl cis-trans isomerase activity that is involved in protein folding, signal transduction, immune regulation, and viral replication[1][7]. Unlike the parent gene, PPIAP20 does not encode a functional protein and is not considered a conventional pharmacological or therapeutic target. Although some pseudogenes can have regulatory functions at the RNA level—such as acting as microRNA sponges or competitive endogenous RNAs, as shown for PPIAP22[4]—there is no evidence that PPIAP20 directly impacts disease mechanisms or is targeted by drugs. PPIAP20 is catalogued in gene/nucleotide databases (e.g., NCBI Gene ID: 100500737), but there is little information about its functional roles or clinical significance[3]. Key distinctions: - This gene should not be confused with its parent gene, PPIA (cyclophilin A), which encodes a widely-studied enzyme implicated in inflammation, infection, cell cycle, and is the target of immunosuppressive drug cyclosporine A[1][5][7]. - Pseudogenes like PPIAP20 may have roles as non-coding RNAs in gene regulation, but current knowledge does not support a clinical or therapeutic role for PPIAP20 itself[4].

Other names

peptidylprolyl isomerase A (cyclophilin A) pseudogene 20PPIAP20