Peptidylprolyl isomerase A pseudogene 23 (PPIAP23)

Peptidylprolyl isomerase A pseudogene 23 (PPIAP23) is classified as a pseudogene, meaning it is a nonfunctional DNA segment that resembles the functional gene encoding peptidylprolyl isomerase A (PPIA)[1][5][6]. Pseudogenes usually arise by duplication or retrotransposition events, often acquiring disabling mutations such as frameshifts or premature stop codons that prevent protein expression[2][6]. PPIAP23 itself does not encode a functional protein and is not considered a direct therapeutic target, receptor, enzyme, or otherwise druggable entity[1][5][6]. Pseudogenes may sometimes regulate gene expression at the RNA level, but there is no evidence for a specific biological, biomarker, or disease role for PPIAP23 at this time[1][2][5][6]. Its primary function is as a genomic sequence homologous to the protein-coding PPIA gene (cyclophilin A), which is distinct and pharmacologically relevant, but PPIAP23 itself has no independent therapeutic or clinical significance.

Other names

PPIAP23