Target intelligence / Profile preview

Peptidylprolyl isomerase A pseudogene 29 (PPIAP29)

Target
PPIAP29
Molecular classification
Pseudogene, Long non-coding RNA
01

Overview

Peptidylprolyl isomerase A pseudogene 29 (PPIAP29) is a non-functional pseudogene related to the peptidylprolyl isomerase A (PPIA, also known as cyclophilin A) gene family. Pseudogenes are genomic DNA sequences similar to known genes but typically do not produce functional proteins due to mutations, insertions, or deletions. While some pseudogenes may have regulatory roles as non-coding RNAs affecting gene expression, there is currently no scientific evidence indicating that PPIAP29 participates in such mechanisms or has any biological function or clinical relevance. PPIAP29 is not recognized as a druggable or therapeutic molecular target. Some pseudogenes of PPIA (e.g., PPIAP22) have experimental evidence for roles as non-coding RNAs affecting cancer progression and gene regulation. However, there is no current evidence that PPIAP29 acts in this way. PPIAP29 should not be confused with "peptidylprolyl isomerase A" (PPIA), which is a well-studied enzyme and drug target. There are no drugs, biomarkers, or therapeutic interventions linked to PPIAP29. If detailed information for the functional protein "Peptidylprolyl isomerase A" (PPIA, cyclophilin A) is needed, it is a different entry with a distinct biological and therapeutic profile.

02

Biological functions

None specific to PPIAP29 described. In general, pseudogenes may act as regulatory non-coding RNAs but no data specific to PPIAP29 is available. Related pseudogenes (for example, PPIAP22) have been shown to act as competing endogenous RNAs (ceRNAs) regulating parental gene expression, but this behavior is not confirmed for PPIAP29.
03

Disease associations

None specific to PPIAP29. No evidence links PPIAP29 itself to disease roles. Other PPIA pseudogenes can regulate parental gene (PPIA) in cancer, but no data for PPIAP29.
04

Safety considerations

None described, not a therapeutic target.

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