Peptidylprolyl isomerase A pseudogene 38 (PPIAP38)

Peptidylprolyl isomerase A pseudogene 38 (PPIAP38) is classified as a processed pseudogene related to the parental gene peptidylprolyl isomerase A (PPIA), also known as cyclophilin A. Pseudogenes are non-functional segments of DNA that resemble functional genes but typically do not produce functional proteins. While some pseudogenes, particularly those expressed as long non-coding RNAs (lncRNAs), can have regulatory roles in gene expression, there is no current evidence associating PPIAP38 with protein function, disease, or therapeutic targeting[3]. There is literature describing another pseudogene in this family—PPIAP22—having some regulatory roles in cancer through ceRNA mechanisms, but no such function has been described or established for PPIAP38[2][4]. Peptidylprolyl isomerase A, the functional parent gene, is involved in protein folding, inflammation, and immune response, and is implicated in various diseases[6]. However, PPIAP38 itself is not documented to contribute to these pathways. The only direct mention of PPIAP38 in research is within gene lists or broad molecular analyses related to psychiatric conditions or genomics but without functional or biomedical validation[3]. PPIAP38, as a pseudogene, is not a canonical drug target or receptor, does not have documented pharmacologic interactions, and its functional significance—if any—remains uncharacterized in current literature[3].

Other names

PPIAP38