Peptidylprolyl isomerase A pseudogene 59 (PPIAP59)

Peptidylprolyl isomerase A pseudogene 59 (PPIAP59) is classified as a human pseudogene with close sequence similarity to the protein-coding PPIA gene, which encodes cyclophilin A, an enzyme involved in protein folding, signal transduction, and immune response[1][6][7]. Unlike PPIA, PPIAP59 does not produce a functional protein and is not implicated in any characterized biological processes, drug interactions, or direct disease roles[10][2]. Pseudogenes such as PPIAP59 may have residual or regulatory roles at the RNA level (as non-coding RNAs), but current data provide no evidence for biological activity, disease relevance, or utility as a therapeutic target for PPIAP59[11]. If a functional or druggable target is desired, the focus should be on peptidylprolyl isomerase A (PPIA) rather than its pseudogene PPIAP59[1][10][2].

Other names

PPIAP59Peptidylprolyl isomerase A pseudogene 59HGNC: 53683NCBI Gene: 390956Ensembl: ENSG00000228674

None applicable — Inactive as a therapeutic target.