Peptidylprolyl isomerase A pseudogene 7 (PPIAP7)

Peptidylprolyl isomerase A pseudogene 7 (PPIAP7) is a human pseudogene located in the genome and designated by the symbol PPIAP7 or alias PPIP7[2][4][6]. As a pseudogene, it is a copied DNA segment resembling the gene for peptidylprolyl isomerase A (PPIA), but it is considered non-coding and does not produce a functional protein. Pseudogenes like PPIAP7 typically arise from gene duplication or retrotransposition events and have lost their ability to encode active proteins due to mutations or truncations[2][4][6]. There is currently no evidence that PPIAP7 functions as a gene product or is druggable, nor is it directly associated with disease in the way active, protein-coding genes are. Mutations or expression changes in other members of the peptidylprolyl isomerase A family, such as the functional PPIA gene (encoding cyclophilin A), have been studied in disease contexts, but those roles do not pertain to PPIAP7[1][5]. Some pseudogenes have been found to regulate gene expression indirectly, but specific regulatory functions for PPIAP7 have not been reported in the available literature or databases[2][4][6]. Clarification: You may encounter related pseudogenes such as PPIAP22, which have been studied for their potential role as competing endogenous RNAs affecting the regulation of functional PPIA and implicated in cancer[5]. However, there are currently no publications or database entries indicating that PPIAP7 shares such functions. If you have a specific interest in the peptidylprolyl isomerase A family’s biological functions, disease roles, or drug relevance, refer to the protein-coding gene Peptidylprolyl isomerase A (PPIA, Cyclophilin A) instead, not this pseudogene[1][3].

Other names

PPIP7