Peptidylprolyl isomerase A pseudogene 83 (PPIAP83)

Peptidylprolyl isomerase A pseudogene 83 (PPIAP83) is annotated as a human pseudogene and does not encode an active protein product[2]. Pseudogenes are generally nonfunctional genomic sequences homologous to known genes, often derived from those via gene duplication or retrotransposition, that have lost coding potential through mutations. While most pseudogenes do not produce functional proteins, some transcribed pseudogenes may have roles as regulatory non-coding RNAs, such as acting as competing endogenous RNAs that bind microRNAs or modulate transcription of their parent genes, as seen with PPIAP43 and other PPIA pseudogenes[3][6]. Evidence supporting a functional or disease-related role for PPIAP83 is lacking, and it is not recognized as a receptor, enzyme, transporter, or therapeutic target in pharmacology or molecular biology databases[2]. Key points: - PPIAP83 is a pseudogene, meaning it does not code for a functional enzyme or receptor and is not a drug target[2]. - Related pseudogenes (such as PPIAP43) have been shown to act as decoys for microRNAs, potentially affecting the regulation of the parental gene PPIA (Cyclophilin A), but there is no specific evidence for such a function for PPIAP83[3][6]. - PPIA, in contrast, is an active enzyme (Cyclophilin A), involved in protein folding and implicated in inflammation, immunity, and infection, but this is distinct from the pseudogene[1]. - No known drugs, biomarkers, or safety concerns are associated with PPIAP83. PPIAP83 should not be confused with the canonical target peptidylprolyl isomerase A (PPIA/cyclophilin A), which is a well-known functional protein[1].

Other names

PPIAP83