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Target intelligence / Profile preview
Peptidylprolyl isomerase B (CypB)
- Target
- CypB
- Molecular classification
- Enzyme, Peptidyl-prolyl cis-trans isomerase, Chaperone
01
Overview
Cyclophilin B (CypB) is a peptidyl-prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of proline residues in proteins, facilitating protein folding. It plays a crucial role in protein folding within the endoplasmic reticulum (ER) and is involved in various cellular processes, including transcriptional regulation and cytokine-like signaling. CypB's involvement in inflammatory diseases, viral infections (like HCV replication), and cancer progression makes it a potential therapeutic target. It interacts with drugs like cyclosporine A, which has clinical significance due to immunosuppressive properties.
- Other names
- PPIBPPIase BCYP-S1SCYLP
02
Mechanism of action
Inhibition of PPIase activity; modulation of protein folding and signaling pathways.
03
Biological functions
Protein foldingTranscriptional regulationCytokine-like signalingProtection against oxidative stressER stress response
04
Disease associations
Inflammatory diseasesViral infectionCancer
05
Safety considerations
Inhibition of CypB by cyclosporine A leads to immunosuppression.
06
Interacting drugs
Cyclosporine A
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