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Peptidylprolyl isomerase E like pseudogene (PPIEL)

Target: PPIEL
Molecular classification: Pseudogene, Related to cyclophilin family (by sequence), but not a member by molecular function

Overview

Peptidylprolyl isomerase E like (PPIEL) is a transcribed pseudogene in humans, closely related in DNA sequence to the functional Peptidylprolyl isomerase E (PPIE) gene. While PPIE is an active cyclophilin involved in protein folding and immune regulation[1][7], PPIEL is not translated into a functional protein, does not participate in catalysis, and is therefore not considered a therapeutic target. However, differential expression or DNA methylation at the PPIEL locus has been observed in some diseases, suggesting possible biomarker value, though its mechanistic significance remains unclear[9][3].

Other names: PPIEP1Peptidylprolyl isomerase E (cyclophilin E) pseudogene 1PPIEL

Biological functions

No confirmed biological function as a proteinPossible regulatory roles at RNA level or via epigenetic changes, but not as an active enzyme

Disease associations

Expression of PPIEL may be downregulated in non-small cell lung cancer (NSCLC)Differential DNA methylation at this locus may be associated with intellectual disability and bipolar disorder in humans

Biomarkers

Possible as a methylation or gene expression biomarker in certain diseases (e.g., NSCLC, intellectual disability, bipolar disorder)

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